一、团队简介

本团队主要进行膜蛋白与心血管功能调节研究；膜蛋白与肿瘤多药耐药研究；药物靶标与诊断标志物的研究。

二、团队负责人简介

马鑫：男，教授，博士生导师，bat365手机版官网BET体育365投注官网副院长。国家自然科学基金优秀青年科学基金项目获得者、国家高技术研究发展计划（863计划）生物和医药技术领域“青年科学家”项目、教育部新世纪优秀人才、江苏省杰出青年基金获得者。

2005年获蚌埠BET体育365投注官网临床医学系学士学位；2007年获浙江大学医学生理学系硕士学位；2010年获香港中文大学BET体育365投注官网博士学位；2010年-2011年间在香港中文大学BET体育365投注官网进行博士后工作。2011年起，在bat365手机版官网工作。

马鑫教授长期从事心血管功能调控与心血管保护研究，以通讯作者/第一作者身份，在美国科学院院刊Proc Natl Acad Sci USA（2012；2014）、J Bio Chem（2015）、美国心脏学会会刊Hypertension（2013）、Arterioscler Thromb Vasc Biol（2010 April;2010 Nov）、Br J Pharmacol（2012）、Pharmacol Res（2015）、Mol Pharmacol（2015）、Biochem Pharmacol（2016）、等发表SCI论文30篇。获得心血管保护方向中国授权专利4项。论文获学术机构Nature子刊Nature/Science-Business eXchange在“Technique in this week”专文报道、Faculty of 1000 medicine在“New Finding, Novel Drug Target”亮点评述。

三、团队成员简介

冯磊：男，副教授。多年来一直从事抗肿瘤血管药物的研发及抗肿瘤血管治疗的评价。在肿瘤血管生成及抗血管治疗方面有较强的研究成果和研究实力。近5年，承担或主要参与了多项国家、省、市级科研项目，指导国家级、省、校级大学生创新项目5项。获得市级科技进步奖2项，中国商业联合会科技进步奖1项，在国内外发表SCI、CSCD科研论文10余篇，获得或申报国家发明专利20余项。

张鹏：男，助理研究员。2011年获得第二军医大学基础部神经生物学硕士学位，2014年获得香港中文大学BET体育365投注官网生物医学博士学位。2014-2015在香港中文大学BET体育365投注官网任副研究员，2016年加入bat365手机版官网。长期从事TRP离子通道在心血管生理病理及肿瘤耐药的机制研究。在SCI期刊发表研究论文11篇，其中第一作者论文4篇。

四、团队代表性科研项目

五、团队代表性科研成果

1. Chen Z, Tang C, Zhu Y, Xie M, He D, Pan Q, Zhang P, Hua D, Wang T, Jin L, Qi X, Zhu Y, Yao X, Jin J,Ma Xin^（#）（2016）.TrpC5 regulates differentiation through the Ca²⁺-Wnt5a signal pathway in colorectal cancer. Clin Sci (Lond). 2 Nov 28.pii: CS20160759.

2. Zhang P, He D, Chen Z, Pan Q, Du F, Zang X, Wang Y, Tang C, Li H, Lu H, Yao X, Jin J,Ma Xin^(#)(2016).Chemotherapy enhances tumor vascularization via Notch signaling-mediated formation of tumor-derived endothelium in breast cancer.Biochem Pharmacol.Oct 15;118:18-30.

3. Zhang P, Mao AQ, Sun CY, Zhang XD, Pan QX, Yang DT, Jin J, Tang CL, Yang ZY, Yao XQ, Lu XJ,Ma Xin^(#)(2016).Translocation of PKG1α acts on TRPV4-C1 heteromeric channels to inhibit endothelial Ca(2+) entry.Acta Pharmacol Sin. Sep;37(9):1199-207

4. He DX, Gu F, Gao F, Hao JJ, Gong D, Gu XT, Mao AQ, Jin J, Fu L^#,Ma Xin^(#)(2016). Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer. Sci Rep. 20;6:24706.

5. He DX, Li GH, Gu XT, Zhang L, Mao AQ, Wei J, Liu DQ, Shi GY^#,Ma Xin^(#)(2016). A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer. Oncotarget. doi: 10.18632/oncotarget.6674.

6. Gu X, Lu C, He D, Lu Y, Jin J, Liu D,Ma Xin^(#)(2016). Notch3 negatively regulates chemoresistance in breast cancers. Tumour Biol. Oct 14.

7. He DX, Zhang GY, Gu XT, Mao AQ, Lu CX, Jin J, Liu DQ,Ma Xin^(#)(2016). Genome-wide profiling of long non-coding RNA expression patterns in anthracycline-resistant breast cancer cells. Int J Oncol. Oct;49(4):1695-1703.

8. Gu X, Lu Y, He D, Lu C, Jin J, Lu X,Ma Xin^(#)(2016). Methylation of Notch3 modulates chemoresistance via P-glycoprotein. Eur J Pharmacol. Dec 5;792:7-14.

9. Zhu Y, Pan Q, Meng H, Jiang Y, Mao A, Wang T, Hua D, Yao X, Jin J^#,Ma Xin^(#)(2015). Enhancement of vascular endothelial growth factor release in long-term drug-treated breast cancer via transient receptor potential channel 5-Ca(2+)-hypoxia-inducible factor 1α pathway. Pharmacol Res. 93:36-42.

10. Wang T, Chen Z, Zhu Y, Pan Q, Liu Y, Qi X, Jin L, Jin J,Ma Xin^(#), Hua D^#(2015). Inhibition of transient receptor potential channel 5 reverses 5-Fluorouracil resistance in human colorectal cancer cells. J Biol Chem.290(1):448-56.

11. He DX, Xia YD, Gu XT, Jin J^#,Ma Xin^(#)(2015). A transcription/translation-based gene signature predicts resistance to chemotherapy in breast cancer. J Pharm Biomed Anal. 102:500-8.

12. Chen Y, Wang L, Zhu Y, Chen Z, Qi X, Jin L, Jin J, Hua D,Ma Xin^(#)(2015). Breast cancer resistance protein (BCRP)-containing circulating microvesicles contribute to chemoresistance in breast cancer. Oncol Lett. 10(6):3742-3748.

13. Zhang FF, Zhu YF, Zhao QN, Yang DT, Dong YP, Jiang L, Xing WX, Li XY, Xing H, Shi M, Chen Y, Bruce IC, Jin J^#,Ma Xin^(#)(2014). Microvesicles mediate transfer of P-glycoprotein to paclitaxel-sensitive A2780 human ovarian cancer cells, conferring paclitaxel-resistance. Eur J Pharmacol. 738:83-90.

14. He DX, Xia YD, Gu XT, Jin J^#,Ma Xin^(#)(2014). A 20-gene signature in predicting the chemoresistance of breast cancer to taxane-based chemotherapy. Mol Biosyst. 10(12):3111-9.

15. He DX, Gu XT, Jiang L, Jin J^#,Ma Xin^(#)(2014). A methylation-based regulatory network for microRNA 320a in chemoresistant breast cancer. Mol Pharmacol. 86(5):536-47.

16. He DX, Gu XT, Li YR, Jiang L, Jin J^#,Ma Xin^(#)(2014). Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAc N-deacetylase/N-sulfotransferase-1 in human breast cancer. FEBS J. 281(20):4718-30.

17. Jiang L, He D, Yang D, Chen Z, Pan Q, Mao A, Cai Y, Li X, Xing H, Shi M, Chen Y, Bruce IC, Wang T, Jin L, Qi X, Hua D, Jin J^#,Ma Xin^(#)(2014). MiR-489 regulates chemoresistance in breast cancer via epithelial mesenchymal transition pathway. FEBS Lett. 588(11):2009-15.

18. Dong Y, Pan Q, Jiang L, Chen Z, Zhang F, Liu Y, Xing H, Shi M, Li J, Li X, Zhu Y, Chen Y, Bruce IC, Jin J^#,Ma Xin^(#)(2014). Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. Biochem Biophys Res Commun. 446(1):85-90.

19. Ma Xin^(#,*), Chen Z^*, Hua D^*, He D^*, Wang L, Zhang P, Wang J, Cai Y, Gao C, Zhang X, Zhang F, Wang T, Hong T, Jin L, Qi X, Chen S, Gu X, Yang D, Pan Q, Zhu Y, Chen Y, Chen D, Jiang L, Han X, Zhang Y, Jin J^#, Yao X (2014). Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proc Natl Acad Sci USA. 111(17):6389-94.

20. Ma Xin^*, Du J^*, Zhang P, Deng J, Liu J, Lam FF, Li RA, Huang Y, Jin J, Yao X^#(2013).Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats. Hypertension. 62(1):134-9.

21. Ma Xin^*, Cai Y^*, He D^*, Zou C, Zhang P, Lo CY, Xu Z, Chan FL, Yu S, Chen Y, Zhu R, Lei J, Jin J^#, Yao X^#(2012). Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proc Natl Acad Sci USA. 109(40):16282-7.

22. He D, Jin J, Zheng Y, Bruce IC, Tam S^#,Ma Xin^(#)(2012). Anti-angiogenesis effect of trichosanthin and the underlying mechanism. FEBS J. 279(10):1834-43.

23. Ma Xin^(#), He D, Ru X, Chen Y, Cai Y, Bruce IC, Xia Q, Yao X, Jin J^#(2012). Apigenin, a plant-derived flavone, activates transient receptor potential vanilloid 4 cation channel. Br J Pharmacol. 166(1):349-58.

24. Ma Xin^(#), Cheng KT, Wong CO, O'Neil RG, Birnbaumer L, Ambudkar IS, Yao X (2011). Heteromeric TRPV4-C1 channels contribute to store-operated Ca(2+) entry in vascular endothelial cells. Cell Calcium. 50(6):502-9.

25. Ma Xin^(#), Nilius B, Wong JW, Huang Y, Yao X (2011). Electrophysiological properties of heteromeric TRPV4-C1 channels. Biochim Biophys Acta. 1808(12):2789-97.

26. Ma Xin^(#), Cao J, Luo J, Nilius B, Huang Y, Ambudkar IS, Yao X^#(2010). Depletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane. Arterioscler Thromb Vasc Biol. 30(11):2249-55.

27. Ma Xin^(#), Qiu S, Luo J, Ma Y, Ngai CY, Shen B, Wong CO, Huang Y, Yao X^#(2010). Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx. Arterioscler Thromb Vasc Biol. 30(4):851-8.

六、团队合影